La maestra te menospreciará si se entera de que has hecho trampa en el examen.The teacher will scorn you if she finds out that you have cheated on the exam.
El personaje más menospreciado del libro acabó siendo el héroe de la trama.The most underestimated character in the book ended up being the hero of the plot.
Que no te demos un salario competitivo no significa que menospreciemos tu trabajo.Although we don't give you a competitive salary, that doesn't mean that we undervalue your contributions.
Creo que Jorge tiene un problema de autoestima. Es muy inteligente, pero se menosprecia constantemente.I think Jorge has a problem with his self-esteem. He's very intelligent, but he puts himself down all the time.