it is extremely difficult

es sumamente difícil

For this reason, it is extremely difficult to overdose with them.	Por esta razón, es extremadamente difícil de sobredosis con ellos.
Nowadays it is extremely difficult, almost impossible to be yourself.	Hoy en día es extremadamente difícil, casi imposible ser uno mismo.
When and how it started, it is extremely difficult to understand.	Cuando y como empezó, es extremadamente difícil de entender.
But it is extremely difficult to eradicate these Trishnas.	Pero es sumamente difícil erradicar estos Trishnas.
Due to this fact, it is extremely difficult to communicate with SCP-1799.	Debido a este hecho, es extremadamente difícil la comunicación con SCP-1799.
Therefore, it is extremely difficult to find a suit in the store.	Por lo tanto, es extremadamente difícil encontrar un traje en la tienda.
It sounds so simple, but it is extremely difficult.	Ello suena tan sencillo; pero es extremadamente difícil.
Because of this, it is extremely difficult to scratch them.	Debido a esto, es extremadamente difícil rascarlos.
But in practice, it is extremely difficult.	Pero en la práctica, es extremadamente difícil.
During the winter months it is extremely difficult to reach the Monastery.	Durante los meses del invierno es extremadamente difícil alcanzar el monasterio.
Moreover, it is extremely difficult to voluntarily renounce your original nationality.	Por cierto, es muy difícil renunciar voluntariamente a una nacionalidad.
This may sound very simple, but it is extremely difficult to do it well.	Puede que suene muy sencillo, pero es extremadamente complicado hacerlo bien.
We know that it is extremely difficult.	Sabemos que es muy difícil.
Lastly, I would like to stress that it is extremely difficult to draw up proposals.	Para terminar, querría subrayar que es muy difícil formular propuestas.
This method is really good, but it is extremely difficult for some people.	Este método es en verdad bueno, pero se torna extremadamente difícil para alguna gente.
Typically, after two elbows, it is extremely difficult to evaluate the signals.	Normalmente, tras el paso por dos codos consecutivos, es muy difícil evaluar las señales.
Understand that it is extremely difficult for some to take responsibility for their own lives.	Entiendan que es extremadamente difícil para algunos asumir la responsabilidad de sus propias vidas.
Not really though it is extremely difficult to play!	Realmente no aunque es extremadamente difícil jugar!
That is why it is extremely difficult to determine what has started the illness.	Es por ello que es extremadamente difícil determinar lo que ha comenzado la enfermedad.
Moreover, most evidence suggests it is extremely difficult to change the financial behavior of adults.	Además, la evidencia sugiere que es sumamente difícil cambiar el comportamiento financiero de los adultos.