In clinical trials, cases of colitis (including intestinal and rectal bleeding, sometimes fatal, intestinal perforation, intestinal necrosis and typhlitis) have been reported uncommonly in patients treated with pemetrexed. | En pacientes tratados con pemetrexed en ensayos clínicos se han notificado, con poca frecuencia, casos de colitis (incluyendo sangrado intestinal y rectal en algunos casos mortales, perforación intestinal, necrosis intestinal y tifilitis). |
Cases of rectal bleeding have been reported in patients taking orlistat. | Se han notificado casos de sangrado rectal con allí. |
Gastrointestinal haemorrhages, including rectal bleeding and melaena have been reported in colorectal cancer patients, and have been assessed as tumour-associated haemorrhages. | En pacientes con cáncer colorrectal se han notificado hemorragias gastrointestinales, incluyendo hemorragia rectal y melena, y se evaluaron como hemorragias asociadas al tumor. |
